Hepatitis C virus drives increased type I interferon-associated impairments associated with fibrosis severity in antiretroviral treatment-treated HIV-1-hepatitis C virus-coinfected individuals
Abstract
On behalf of the HepACT-VIH study group - Viral coinfections might contribute to the increased immune activation and inflammation that persist in antiretroviral treatment (ART)-treated HIV-1 patients. We investigated whether the hepatitis C virus (HCV) coinfection contributes to such alterations by impairing the plasmacytoid dendritic cell (pDC) IFNa/TLR7 pathway in a highly homogeneous group of ART-treated HIV-1-HCV-coinfected patients.
Domains
Immunology
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Hepatitis_C_virus_drives_increased_type_I.4 (1).pdf (1.98 Mo)
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