Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging - Université Jean-Monnet-Saint-Étienne Access content directly
Journal Articles Journal of the American Chemical Society Year : 2008

Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging

Abstract

Functionalized gold nanoparticles were applied as contrast agents for both in vivo X-ray and magnetic resonance imaging. These particles were obtained by encapsulating gold cores within a multilayered organic shell which is composed of gadolinium chelates bound to each other through disulfide bonds. The contrast enhancement in MRI stems from the presence of gadolinium ions which are entrapped in the organic shell whereas the gold core provides a strong X-ray absorption. This study revealed that these particles suited for dual modality imaging freely circulate in the blood vessels without undesirable accumulation in lungs, spleen and liver.

Dates and versions

ujm-00350670 , version 1 (07-01-2009)

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Cite

Christophe Alric, Jacqueline Taleb, Géraldine Le Duc, Celine Mandon, Claire Billotey, et al.. Gadolinium chelates coated gold nanoparticles as contrast agents for both X-ray computed tomography and magnetic resonance imaging. Journal of the American Chemical Society, 2008, 130 (18), pp.5908-5915. ⟨10.1021/ja078176p⟩. ⟨ujm-00350670⟩
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