Effective information retrieval on handwritten document images has always been a challenging task, especially historical ones. In the paper, we propose a coarse-tofine handwritten word spotting approach based on the graph representation. The presented model comprises both the topological and morphological signatures of the handwriting. Skeleton-based graphs with the Shape Context labelled vertexes are established for connected components. Each word image is represented as a sequence of graphs. Aiming at developing a practical and efficient word spotting approach for large-scale historical handwritten documents, a fast and coarse comparison is first applied to prune the regions that are not similar to the query based on the graph embedding methodology. Afterwards, the query and regions of interest are compared by graph edit distance based on the Dynamic Time Warping alignment. The proposed approach is evaluated on a public dataset containing 50 pages of historical marriage license records. The results show that the proposed approach achieves a compromise between efficiency and accuracy.