In addition to controlling surface wettability, femtosecond laser surface texturing of materials by direct laser ablation has a wide range of applications, specifically for virus and bacterial repulsion. However, because of chemical surface alterations such as oxidation and/or molecule adsorption, the wettability of laser-textured surfaces alternates over time [1–2]. The reasons for this effect are not yet properly understood, despite their significance. To further understand these effects, we have developed a multiscale model, in which reactive molecular dynamics (RMD) is used to simulate chemical surface alterations while computational fluid dynamics (CFD) is used to quantify droplet behavior on laser-textured metal surfaces [3]. In particular, surface oxidation and molecule adsorption at the interface of a femtosecond laser were simulated using RMD. The obtained reaction rates are then utilized to modify a number of the CFD model's interface settings. The simulation's results demonstrate how the amount of surface-attached oxygen influences the evolution of water droplets.