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Article Dans Une Revue Computers & Industrial Engineering Année : 2022

The multi-trip vehicle routing problem with increasing profits for the blood transportation: An iterated local search metaheuristic

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Abstract The identity of histocompatibility loci, besides human leukocyte antigen ( HLA ), remains elusive. The major histocompatibility complex (MHC) class I MICA gene is a candidate histocompatibility locus. Here, we investigate its role in a French multicenter cohort of 1,356 kidney transplants. MICA mismatches were associated with decreased graft survival (hazard ratio (HR), 2.12; 95% confidence interval (CI): 1.45–3.11; P < 0.001). Both before and after transplantation anti-MICA donor-specific antibodies (DSA) were strongly associated with increased antibody-mediated rejection (ABMR) (HR, 3.79; 95% CI: 1.94–7.39; P < 0.001; HR, 9.92; 95% CI: 7.43–13.20; P < 0.001, respectively). This effect was synergetic with that of anti-HLA DSA before and after transplantation (HR, 25.68; 95% CI: 3.31–199.41; P = 0.002; HR, 82.67; 95% CI: 33.67–202.97; P < 0.001, respectively). De novo-developed anti-MICA DSA were the most harmful because they were also associated with reduced graft survival (HR, 1.29; 95% CI: 1.05–1.58; P = 0.014). Finally, the damaging effect of anti-MICA DSA on graft survival was confirmed in an independent cohort of 168 patients with ABMR (HR, 1.71; 95% CI: 1.02–2.86; P = 0.041). In conclusion, assessment of MICA matching and immunization for the identification of patients at high risk for transplant rejection and loss is warranted.
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hal-04453730 , version 1 (22-07-2024)

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Andrea Pirabán-Ramírez, William Javier Guerrero-Rueda, Nacima Labadie. The multi-trip vehicle routing problem with increasing profits for the blood transportation: An iterated local search metaheuristic. Computers & Industrial Engineering, 2022, 170 (5), pp.108294. ⟨10.1016/j.cie.2022.108294⟩. ⟨hal-04453730⟩
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