Study of Stromal Femtosecond Laser Ablation for Deep Corneal Cut Optimization - Université Jean-Monnet-Saint-Étienne Access content directly
Journal Articles Journal of laser Micro/Nano Engineering Year : 2012

Study of Stromal Femtosecond Laser Ablation for Deep Corneal Cut Optimization

Abstract

Femtosecond laser (FL) has become a common tool in corneal surgery during the last years. The first clinical application of FL in ophthalmology was in refractive surgery for the cutting of superficial cornea flaps in transparent corneas. Recently, FL applications have been extended to penetrating and anterior or posterior lamellar corneal grafts. However, commercially available FL in ophthalmology have already shown limitations in these new applications, particularly in oedematous cornea (secondary to corneal diseases or occurring during storage by eye banks) that cause light scattering during stromal crossing. In order to improve these cuts, knowledge on the biological material, namely corneal stroma, is essential. Moreover, collagen organization of anterior corneal stroma is more compact compared to the posterior one, but the influence of these structural differences on the cut has never been studied. In this work, we compared ablation rates (ARs) in anterior and posterior human corneal stroma, isolated from the rest of the cornea by mechanical dissection in order to eliminate the scattering effect. ARs were quantified using Second Harmonic Generation microscopy. Results showed significantly higher ARs in posterior corneal stroma (+23±12% (mean±SD); P=0.0038). Previously reported limitations to cut the posterior stroma with FL can therefore not be explained by the difference in collagen organization but by the optical scattering during stromal crossing.

Dates and versions

ujm-00757490 , version 1 (27-11-2012)

Identifiers

Cite

Aurélien Bernard, Éric Audouard, Gilles Thuret, Michel Peoc'H, Jean-Marc Dumollard, et al.. Study of Stromal Femtosecond Laser Ablation for Deep Corneal Cut Optimization. Journal of laser Micro/Nano Engineering, 2012, 7 (3), pp.351-354. ⟨10.2961/jlmn.2012.03.0021⟩. ⟨ujm-00757490⟩
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